Figure 13.
Schematic presentation of exocytosis and endocytosis of GluA1-containing AMPAR during LTD. A, In a basal condition, AMPAR traffics through exocytosis, clathrin- and dynamin-independent endocytosis, and lateral diffusion. B, Soon after NMDA application (∼1 min), clathrin- and dynamin-dependent endocytosis occurs together with enhanced exocytosis around the postsynaptic membrane. C, In the slowly decreasing phase (2–5 min) of cell-surface AMPAR, the exocytosis is suppressed. Endocytosis is also suppressed slightly, and the amount of PSD95 is decreased. Arrow sizes reflect relative frequencies of exocytosis and endocytosis.