Figure 1. Left ventricular function in 146 patients with arrhythmogenic cardiomyopathy and known exercise habits at presentation.

Slopes are fitted mean linear response with 95% CIs for patients with and without desmoplakin mutations. P values for progression and interaction by linear mixed‐model regression with random effects for families and individuals and exchangeable covariance structure. Exercise during 3 immediate years before presentation expressed as average MET‐hours per week, with dichotomization at median exercise exposure. Patients with exercise exposure above median had GLS 1.0% (interquartile range, 0.1%–1.9%; P=0.02) worse than patients with exercise exposure below median. There was no difference in the progression of left ventricular dysfunction in patients with greater or lesser exercise exposure (illustrated by P for interaction=0.87). See Table 2 for coefficients and continuous exercise variable. GLS indicates global longitudinal strain; and LV, left ventricular.