Table 4.
Global and Regional LV Strain and Dyssynchrony at Year 10 in Relation to NT‐proBNP Quartiles (N=2211)
| Models* | NT‐proBNP Quartiles (pg/mL) | P Trend † | |||
|---|---|---|---|---|---|
|
Q1 (Low, 5 to <24) N=641 |
Q2 (24 to <55) N=582 |
Q3 (55 to <112) N=564 |
Q4 (High, ≥112) N=424 |
||
| Adjusted Mean (95% CI) | |||||
| Peak systolic circumferential strain (ECC), % | |||||
| Global | |||||
| Model 1 | −18.1 (−18.3 to −17.9) | −18.1 (−18.3 to −17.9) | −18.1 (−18.3 to −17.9) | −18.0 (−18.2 to −17.8) | 0.637 |
| Model 2 | −18.2 (−18.4 to −18.0) | −18.1 (−18.3 to −17.9) | −18.0 (−18.2 to −17.8) | −17.9 (−18.2 to −17.7) | 0.132 |
| Basal | |||||
| Model 1 | −17.0 (−17.2 to −16.7) | −16.9 (−17.2 to −16.7) | −16.8 (−17.1 to −16.6) | −16.4 (−16.8 to −16.3) ‡ | 0.106 |
| Model 2 | −17.0 (−17.2 to −16.8) | −17.0 (−17.2 to −16.7) | −16.7 (−17.0 to −16.5) | −16.4 (−16.7 to −16.2)§ | 0.014 |
| Mid | |||||
| Model 1 | −18.1 (−18.3 to −17.9) | −18.1 (−18.3 to −17.9) | −18.2 (−18.4 to −17.9) | −18.1 (−18.4 to −17.8) | 0.746 |
| Model 2 | −18.1 (−18.4 to −17.9) | −18.1 (−18.3 to −17.9) | −18.1 (−18.3 to −17.9) | −18.0 (−18.3 to −17.8) | 0.716 |
| Apical | |||||
| Model 1 | −19.3 (−19.5 to −19.0) | −19.2 (−19.4 to −19.0) | −19.2 (−19.4 to −19.0) | −19.2 (−19.4 to −19.1) | 0.965 |
| Model 2 | −19.3 (−19.5 to −19.1) | −19.2 (−19.5 to −19.0) | −19.2 (−19.5 to −19.0) | −19.1 (−19.4 to −18.9) | 0.046 |
| Standard deviation of time to peak systolic circumferential strain, ms | |||||
| Global | |||||
| Model 1 | 3.7 (3.6 to 3.9) | 3.8 (3.7 to 3.8) | 3.8 (3.7 to 3.9) | 3.9 (3.8 to 4.0) ‡ | 0.014 |
| Model 2 | 3.7 (3.6 to 3.8) | 3.8 (3.7 to 3.8) | 3.8 (3.7 to 3.9) | 3.9 (3.8 to 4.0) ‡ | 0.016 |
| Basal | |||||
| Model 1 | 3.6 (3.5 to 3.8) | 3.6 (3.5 to 3.7) | 3.6 (3.5 to 3.7) | 3.7 (3.6 to 3.9) | 0.447 |
| Model 2 | 3.7 (3.5 to 3.8) | 3.6 (3.5 to 3.7) | 3.6 (3.5 to 3.7) | 3.7 (3.5 to 3.9) | 0.758 |
| Mid | |||||
| Model 1 | 3.6 (3.5 to 3.7) | 3.6 (3.4 to 3.7) | 3.6 (3.5 to 3.7) | 3.7 (3.5 to 3.9) | 0.080 |
| Model 2 | 3.6 (3.5 to 3.7) | 3.6 (3.4 to 3.7) | 3.6 (3.5 to 3.7) | 3.7 (3.5 to 3.8) | 0.043 |
| Apical | |||||
| Model 1 | 3.3 (3.2 to 3.4) | 3.4 (3.3 to 3.5) | 3.4 (3.3 to 3.6) | 3.4 (3.2 to 3.5) | 0.073 |
| Model 2 | 3.3 (3.2 to 3.4) | 3.4 (3.3 to 3.5) | 3.4 (3.3 to 3.6) | 3.5 (3.3 to 3.6) ‡ | 0.041 |
ECC denotes circumferential shortening and is normally negative; less negative values of ECC reflect decreased regional function. CAC, coronary artery calcium; LV, left ventricular; and NT‐proBNP, N‐terminal pro‐B‐type natriuretic peptide.
Model 1: adjusted for age, sex, and race (White [reference], African‐American, Chinese, Hispanic); Model 2: adjusted for all variables in model 1 plus education more than high school, physical activity (sex‐specific tertiles: low, middle, high), current cigarette smoking, diabetes mellitus, body mass index, systolic blood pressure, antihypertensive medication use, high‐density lipoprotein cholesterol, total cholesterol, statin medication use, prevalence of CAC score >10, and LV mass.
P for linear trend tested by entering log (NT‐proBNP) as a continuous variable in the same model.
P<0.05, § P<0.01.