Skip to main content
. 2021 Mar 9;10(6):e017128. doi: 10.1161/JAHA.120.017128

Figure 1. Family pedigree and clinical expression of G3118R mutation.

Figure 1

A, Family pedigree. B, Exercise‐induced ventricular bigeminy and bidirectional couplet of patient IV1. aVR, augmented Vector Right; aVL, augmented Vector Left; and aVF, augmented Vector Foot. C, Initiation of VF of patient IV13. D, Chromatograms of homozygous patient IV13 (left) showing adenine replacing guanine in position 237863752 of chromosome 1 in both alleles (arrow) and her heterozygous father (right). E, RyR2 three‐dimensional reconstruction, with G3118R amino acid region circled. PVCs, premature ventricular contractions; VF, ventricular fibrillation; and VT, ventricular tachycardia.