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. 2021 Mar 5;10(6):e018097. doi: 10.1161/JAHA.120.018097

Figure 2. AdipoRon modulates cardiopulmonary bypass (CPB)–induced changes in blood concentrations of K+, lactate, and cytokines.

Figure 2

Blood levels of (A) lactate and (B) K+ as well as (C) the cytokines TNF‐α (tumor necrosis factor α), IL (interleukin) 1β, IL‐6, and IL‐10 were measured in AdipoRon‐ and vehicle‐treated rats before CPB (T1), at 25°C in the cooling phase (T2), at 20°C (T3) and 35°C (T4) in the rewarming phase, and after 60 minutes of reperfusion (T5). Results for T1 to T5 are presented as mean±SEM (n=7 animals per group). Differences of blood parameter values were analyzed statistically by comparing the experimental groups CPB‐Vehicle and CPB‐AdipoRon at the indicated time points. No statistically significant intergroup differences were observed. Values of P≥0.10 are not shown.