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. 2021 Mar 5;10(6):e018097. doi: 10.1161/JAHA.120.018097

Figure 4. AdipoRon does not affect cardiopulmonary bypass (CPB)–induced myocardial injury.

Figure 4

A, Myocardial activation of apoptosis marker caspase‐3 (CASP‐3) in AdipoRon‐ and vehicle‐treated animals was analyzed by immunoblot after completion of the experimental CPB procedure. Upper panel: representative pictures of the uncleaved (molecular weight: 35 kDa) and cleaved CASP‐3 (molecular weight: 17 kDa) band patterns. Lower panel: column bars indicate quantified levels of cleaved CASP‐3/CASP‐3 expression ratios. B, Serum levels of troponin T were measured at the end of the reperfusion phase (T5) in AdipoRon‐ and vehicle‐treated animals. Results are presented as mean+SEM (n=7 animals per group). Differences of marker expression levels between experimental groups were analyzed statistically by performing the indicated pairwise comparisons.