Table 6.

Cox Proportional Hazard Models for Death, Myocardial Infarction, and Cardiovascular Disease Mortality

	Death			MI			CVD Mortality
LSNS	1.46* (1.28, 1.65)	1.46* (1.28, 1.65)	1.46* (1.29, 1.66)	1.10 (0.84, 1.44)	1.10 (0.84, 1.45)	1.10 (0.84, 1.44)	1.23 † (0.96, 1.58)	1.23 † (0.96, 1.58)	1.24 † (0.97, 1.59)
RMSSD		1.00 (1.00, 1.00)	1.01* (1.00, 1.01)		1.00 (1.00, 1.00)	1.00 † (1.00, 1.01)		1.00 (1.00, 1.00)	1.01* (1.00, 1.01)
SDNN			0.99* (0.99, 0.99)			0.99* (0.99, 1.00)			0.99* (0.98, 1.00)

The initial models used social isolation as the exposure, with subsequent models adjusted for RMSSD and SDNN. All models included adjustment for age, sex, body mass index, race, hypertension, CHD, and diabetes mellitus. CVD indicates cardiovascular disease; LSNS, Lubben Social Network Scale; MI, myocardial infarction; RMSSD, the root mean square of successive differences in normally conducted RR intervals; and SDNN, the SD of normally conducted RR intervals.

^* P<0.001.

^† P<0.05.