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A and B, Overexpression of SIRT3 led to a significant improvement of EF% and FS% with reduction of heart weight (HW/tibia length ratio) in db/db mice. All data represent mean±SD (n=5–8 mice, *P<0.05, **P<0.01, and ***P<0.001). Ad‐SIRT3 indicates adenovirus SIRT3; EF%, ejection fraction; and FS%, fractional shortening.
