Table 2.

Measurement of Heart Rate and Cardiac Function by Echocardiography

	Db+/− Mice (n=5)	Db/db+Adenovirus‐β‐gal (n=8)	Db/db+Adenovirus‐SIRT3 (n=5)	P Value
Heart rate, bpm	485±30	425±60	435±50
LVSD, mm	2.37±0.033	2.88±0.02*	2.58±0.037 †	<0.05
LVDD, mm	3.86±0.026	4.36±0.032*	4.19±0.32*
LVSV, µL	19.89±0.685	31.85±0.531*	27.57±1.11 †	<0.05
LVDV, µL	64.73±1.06	86.26±1.47*	84.9±1.803*
Stroke volume, µL	44.84±0.61	54.41±1.233*	57.33±0.888*
Cardiac output, mL/min	19.76±0.165	23.59±0.539*	25.21±0.356*

All data represent mean±SD. One‐way ANOVA, followed by Tukey's post‐hoc test. LVDD indicates left ventricular end‐diastolic diameter; LVDV, left ventricular end‐diastolic volume; LVSD, left ventricular end‐systolic diameter; and LVSV, left ventricular end‐systolic volume.

^* P<0.05 vs db+/−.

^† P<0.05 vs Db/db+Ad‐β‐gal.