Table 2.
Demographic and Clinical Characteristics of Patients With HCM With or Without FHOD3 Candidate Variants
| Variable | FHOD3 Variant Carriers | Noncarriers | P Value* |
|---|---|---|---|
| Sample size | 33 | 967 | |
| Age at enrollment, y | 45.2±17.2 | 48.0±14.5 | 0.282 |
| Age at diagnosis, y | 40.0±14.5 | 43.5±14.6 | 0.179 |
| Men, n (%) | 24 (72.7) | 622 (64.3) | 0.321 |
| BMI, kg/m2 | 24.6±2.8 | 25.6±3.7 | 0.133 |
| Family history of SCD, n (%) | 4 (12.1) | 112 (11.6) | 0.847 |
| Echocardiography | |||
| MVT, mm | 23.6±6.9 | 22.6±5.8 | 0.340 |
| Left atrium, mm | 43.0±6.8 | 41.7±7.2 | 0.300 |
| LVEDD, mm | 45.1±7.7 | 44.0±6.3 | 0.327 |
| Ejection fraction, % | 66.3±11.3 | 67.6±8.1 | 0.372 |
| Outflow tract obstruction, n (%) | 19 (57.6) | 544 (56.3) | 0.881 |
Continuous variables are presented as mean±SD; the categorical variable sex was presented as number (percentage). BMI indicates body mass index; FHOD3, formin homology 2 domain‐containing 3; HCM, hypertrophic cardiomyopathy; LVEDD, left ventricular end‐diastolic diameter; MVT, maximal left ventricular wall thickness; and SCD, sudden cardiac death.
*
Continuous variables were compared by Student t test; the categorical variables were compared by χ2 test.