Table 3.

Univariable and Multivariable Cox Regression Analysis of the Association Between FHOD3 Candidate Variants and Cardiovascular Death in Patients With HCM

Variants	Crude HR (95% CI)	Crude P Value	Adjusted HR (95% CI)	Adjusted P Value
FHOD3 variants	4.086 (1.480–9.221)	0.009	3.707 (1.320–8.594)	0.016
LVEDD	1.066 (1.025–1.103)	0.002	1.071 (1.025–1.113)	0.003
Family history of SCD	2.258 (1.035–4.473)	0.041	2.276 (1.032–4.580)	0.042
MVT	1.034 (1.002–1.214)	0.042	1.046 (0.9991–1.101)	0.102
Left atrial diameter	1.047 (1.006–1.086)	0.025	1.020 (0.977–1.062)	0.361

FHOD3 indicates formin homology 2 domain‐containing 3; HCM, hypertrophic cardiomyopathy; HR, hazard ratio; LVEDD, left ventricular end‐diastolic diameter; MVT, maximal left ventricular wall thickness; and SCD, sudden cardiac death.