Table 1.

Physical Capacity Obtained in the Maximal Exercise Test in MMTV‐PyMT− and MMTV‐PyMT+ Mice at the Beginning and End of Experimental Protocol

Variable	MMTV‐PyMT−		MMTV‐PyMT+		P Group	P Time	P Interaction
	Pre	Post	Pre	Post
Distance, m	703.4±128.5	599.1±224.7	653.1±95.9	384.9±187.6	0.003*	<0.001*	0.079
Time, min	35.9±3.4	32.9±6.2	34.6±2.5	25.7±6.4	0.001*	<0.001*	0.031*
Velocity, m/min	36.2±3.3	33.7±6.3	34.9±2.8	26.6±6.6	0.002*	<0.001*	0.037*

Generalized estimation equations with normal distribution and identity link function using AR(1) correlation matrix between evaluations. Values are expressed as means±SD. One mouse in the mouse mammary tumor virus–polyomavirus middle T antigen (MMTV‐PyMT)− group and 1 mouse in the MMTV‐PyMT+ group were not included in exercise tolerance test. The MMTV‐PyMT− mouse refused to run on the treadmill, while the MMTV‐PyMT+ mouse had its stride motion compromised by the tumor. Thus, 13 mice in the MMTV‐PyMT− and 14 mice in the MMTV‐PyMT+ groups were included in this study.

^* Significant difference.