Table 3.

Associations of Adiponectin and Leptin With Markers of Subclinical CVD in the Study of Women's Health Across the Nation

	No.	cIMT				No.	AD				No.	baPWV
		Estimate	SE	P Value	R 2		Estimate	SE	P Value	R 2		Estimate	SE	P Value	R 2
Adiponectin
Model 1	1344	−0.016	0.005	0.001	0.108	1337	−0.141	0.029	<0.001	0.072	1056	−41.213	11.255	<0.001	0.101
Model 2	1344	−0.013	0.005	0.007	0.115	1337	−0.127	0.029	<0.001	0.079	1056	−38.630	11.410	<0.001	0.105
Model 3	1344	−0.007	0.005	0.195	0.131	1337	−0.070	0.029	0.017	0.114	1056	−36.198	11.694	0.002	0.106
Model 4*	1326	0.002	0.005	0.649	0.168	1323	0.035	0.032	0.281	0.204	1015	−11.240	10.927	0.304	0.302
Leptin
Model 1	1323	0.020	0.004	<0.001	0.123	1326	0.156	0.021	<0.001	0.093	1047	−4.487	8.617	0.603	0.090
Model 2	1323	0.020	0.004	<0.001	0.134	1326	0.165	0.021	<0.001	0.106	1047	−3.691	8.874	0.678	0.095
Model 3	1323	0.012	0.005	0.006	0.136	1326	0.100	0.026	<0.001	0.119	1047	−16.456	10.614	0.121	0.099
Model 4*	1315	0.008	0.004	0.091	0.171	1318	0.057	0.025	0.021	0.202	1006	−33.237	9.568	<0.001	0.309

Both adioponectin and leptin were log‐transformed for analyses; thus, estimates shown represent the difference in carotid artery intima‐medial thickening, adventitial diameter, and brachial artery pulse wave velocity per 1‐unit increase in adiponectin (top rows) or leptin (bottom rows), respectively. Model 1 covariates: age, race/ethnicity, and study site. Model 2 covariates: Model 1+smoking, and alcohol consumption. Model 3 covariates: Model 2+obesity status (body mass index <30 vs ≥30). Model 4 covariates: Model 3+systolic blood pressure, and fasting glucose for all outcomes. AD indicates adventitial diameter; baPWV, brachial artery pulse wave velocity; and cIMT, carotid artery intima‐medial thickening.

^*Menopausal status is an added covariate in Model 4 for carotid artery intima‐medial thickening and adventitial diameter outcomes (for both the adiponectin and leptin models); high‐density lipoprotein cholesterol is an added covariate for Model 4 for adventitial diameter for just the adiponectin model; and low‐density lipoprotein cholesterol is a covariate in both Model 4s with brachial artery pulse wave velocity as the outcome.