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. 2021 Mar 23;10(7):e020053. doi: 10.1161/JAHA.120.020053

Figure 2. Unmatched win ratio analysis.

Figure 2

End point hierarchy from highest to lowest priority of ordered cardio/kidney composite end point definition. A: Cardiac (excluding fatal stroke) or kidney death; B: KF; C: HHF; D1: sustained eGFR decline of ≥40%; D2: doubling of serum creatinine; E: sustained progression to macroalbuminuria. Number (percent) of pairs winning for placebo (gray bar) or empagliflozin (red bar). Number of pairs in analysis: 10 934 771. Number of patient pairs (empagliflozin, placebo) for which no decision on winning can be made (ie, for all end points, either both patients are censored or 1 patient is censored before the other patient having an event: Composite 1: 8 683 755 (79.4%); Composite 2: 9 360 288 (85.6%); Composite 3: 9 603 349 (87.8%). Counting 1 event/participant and type. aNumber of kidney deaths=3. bKF=sustained eGFR <15 mL/min per 1.73 m2 or sustained continuous kidney replacement therapy (including transplantation). eGFR indicates estimated glomerular filtration rate, equation developed by Chronic Kidney Disease Epidemiology Collaboration; HHF, hospitalization for heart failure; HR, hazard ratio; and KF, kidney failure.