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. 2021 Mar 28;10(7):e018905. doi: 10.1161/JAHA.120.018905

Figure 2. Fibrosis in fat pads.

Figure 2

A, Representative Masson trichrome (MT) staining of perivascular adipose tissue surrounding the saphenous vein (SV‐PVAT), that surrounding the internal thoracic artery (ITA‐PVAT), that surrounding the coronary artery (CA‐PVAT), and that surrounding the aorta (Ao‐PVAT). Bar=200 µm. B, Fibrosis areas in SV‐PVAT, ITA‐PVAT, CA‐PVAT, and Ao‐PVAT of patients (n=28). Results are shown as means±SD. C, Gene expression levels of fibrosis‐related molecules, including transforming growth factor‐β (TGF‐β), tissue inhibitor of metalloproteinase 1 (TIMP1), platelet‐derived growth factor subunit B (PDGFB), and macrophage‐inducible C‐type lectin (MINCLE), in SV‐PVAT, ITA‐PVAT, CA‐PVAT, and Ao‐PVAT. Results are shown as relative expression of each target gene in SV‐PVAT of each patient (n=48) and as means±SEM for quantitative real‐time polymerase chain reaction data. AU indicates arbitrary unit. *P<0.05 vs SV‐PVAT, † P<0.05 vs ITA‐PVAT, ‡ P<0.05 vs CA‐PVAT.