Table 2.
Clinical Profiles by TI Score Quintile Groups
| Variable | Five Groups of TI Score | P‐for‐Difference | ||||
|---|---|---|---|---|---|---|
|
G1 (n, 248) [−1 to −0.5] |
G2 (n, 560) (−0.5 to −0.25) |
G3 (n, 529) [−0.25 to 0] |
G4 (n, 1209) [0] |
G5 (n, 387) [0 to 1] |
||
| TI score | −0.78±0.17 | −0.41±0.08 | −0.17±0.06 | 0 | 0.24±0.15 | |
| Observed medication changes | 0.41±0.82 | 0.48±0.95 | 0.78±1.24 | 0.21±0.64 | 2.39±2.14 | <0.01 |
| Predicted medication changes | 4.44±3.35 | 2.78±2.07 | 2.19±1.59 | 0.21±0.64 | 0.60±1.32 | <0.01 |
| Number of clinic visits | 5.73±4.29 | 5.92±3.86 | 8.76±3.58 | 4.49±3.39 | 8.46±4.99 | <0.01 |
| Male sex | 165 (67%) | 349 (62%) | 318 (60%) | 736 (61%) | 220 (57%) | 0.16 |
| Age, y | 65.4±12.0 | 68.8±11.6 | 66.7±11.7 | 66.2±13.4 | 67.1±11.4 | <0.01 |
| Pre‐stroke disability | 49 (20%) | 114 (20%) | 86 (16%) | 173 (14%) | 61 (16%) | 0.01 |
| Baseline National Institutes of Health Stroke score | 3 [1–5] | 3 [2–6] | 3 [1–5] | 3 [1–7] | 3 [1–7] | <0.01 |
| Stroke mechanisms | <0.01 | |||||
| Large artery atherosclerosis | 104 (42%) | 237 (42%) | 213 (40%) | 427 (35%) | 129 (33%) | |
| Small‐vessel occlusion | 63 (25%) | 128 (23%) | 115 (22%) | 235 (19%) | 49 (13%) | |
| Cardioembolism | 30 (12%) | 85 (15%) | 97 (18%) | 269 (22%) | 120 (31%) | |
| Other determined etiology | 2 (0.1%) | 7 (0.1%) | 9 (0.2%) | 31 (0.3%) | 7 (0.2%) | |
| Undetermined etiology | 49 (19%) | 103 (18%) | 95 (18%) | 247 (20%) | 82 (21%) | |
| Recanalization treatment | 22 (9%) | 63 (11%) | 63 (12%) | 187 (16%) | 62 (16%) | <0.01 |
| History of stroke | 59 (24%) | 127 (23%) | 121 (23%) | 234 (19%) | 82 (21%) | 0.28 |
| Hypertension | 213 (86%) | 453 (81%) | 433 (82%) | 725 (60%) | 331 (86%) | <0.01 |
| Diabetes mellitus | 172 (71%) | 283 (51%) | 180 (34%) | 312 (26%) | 92 (24%) | <0.01 |
| Dyslipidemia | 112 (45%) | 238 (43%) | 224 (42%) | 495 (41%) | 134 (35%) | 0.06 |
| Habitual smoking | 113 (46%) | 239 (43%) | 223 (42%) | 487 (40%) | 142 (37%) | 0.18 |
| Atrial fibrillation | 28 (11%) | 85 (15%) | 87 (16%) | 239 (20%) | 108 (28%) | <0.01 |
| Hemoglobin | 13.8±2.1 | 13.6±2.1 | 13.9±1.7 | 13.6±1.9 | 13.6±2.0 | 0.11 |
| Total cholesterol | 180±45 | 177±42 | 177±41 | 175±41 | 175±39 | 0.56 |
| Blood urea nitrogen | 18.7±10.5 | 17.2±7.2 | 16.9±8.3 | 16.2±7.6 | 16.4±7.4 | <0.01 |
| Creatinine | 1.31±1.81 | 1.05±0.85 | 0.98±0.79 | 0.95±0.73 | 0.97±0.79 | <0.01 |
| Fasting blood glucose | 126±55 | 120±55 | 111±39 | 110±45 | 109±41 | <0.01 |
| SBPe | 160±29 | 153±29 | 151±27 | 142±24 | 148±27 | <0.01 |
| DBP | 90±17 | 87±16 | 86±16 | 85±16 | 86±16 | <0.01 |
| mRS score 0–1 at discharge | 122 (49%) | 242 (43%) | 273 (52%) | 575 (48%) | 191 (49%) | 0.08 |
| SBP during the follow‐up period | 141.7±10.3 | 136.2±10.4 | 133.0±10.9 | 124.6±9.7 | 128.9±114.4 | <0.01 |
| DBP during the follow‐up period | 80.7±7.6 | 78.7±8.1 | 77.4±9.5 | 74.6±6.6 | 75.7±7.1 | <0.01 |
| Recurrent stroke | 42 (17%) | 31 (6%) | 12 (2%) | 81 (7%) | 9 (2%) | <0.01 |
Values are presented as means±SDs, medians [interquartile ranges], or frequencies (percentages), respectively. DBP indicates diastolic blood pressure; mRS, modified Rankin Scale; SBP, systolic blood pressure; and TI, treatment intensification.