Table 2.
Associations of Prebeta‐1 HDL Tertiles With CHD and MI in Cohort 2
| ORs | CHD | MI | ||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Unadjusted | ||||
| Percent prebeta‐1 HDL tertile 1 | 1.00 (reference) | — | 1.00 (reference) | — |
| Tertile 2 | 1.67 (1.21–2.29) | 0.002 | 1.75 (1.10–2.78) | 0.017 |
| Tertile 3 | 2.09 (1.53–2.87) | <0.001 | 2.26 (1.44–3.53) | <0.001 |
| Adjusted | ||||
| Percent prebeta‐1 HDL tertile 1 | 1.00 (reference) | — | 1.00 (reference) | — |
| Tertile 2 | 1.42 (0.97–2.09) | 0.076 | 1.38 (0.82–2.31) | 0.226 |
| Tertile 3 | 1.81 (1.20–2.73) | 0.005 | 2.12 (1.24–3.63) | 0.006 |
| Unadjusted | ||||
| Absolute prebeta‐1 HDL tertile 1 | 1.00 (reference) | — | 1.00 (reference) | — |
| Tertile 2 | 1.62 (1.18–2.24) | 0.003 | 1.74 (1.11–2.71) | 0.015 |
| Tertile 3 | 2.24 (1.64–3.07) | <0.001 | 1.79 (1.15–2.79) | 0.010 |
| Adjusted | ||||
| Absolute prebeta‐1 HDL tertile 1 | 1.00 (reference) | — | 1.00 (reference) | — |
| Tertile 2 | 1.28 (0.86–1.90) | 0.220 | 1.53 (0.92–2.57) | 0.105 |
| Tertile 3 | 2.12 (1.41–3.20) | <0.001 | 1.90 (1.09–3.30) | 0.024 |
Unadjusted and adjusted ORs and 95% CIs for tertiles of both percent prebeta‐1 HDL (percent of total plasma apolipoprotein A‐I) and absolute prebeta‐1 HDL. ORs were determined by logistic regression and adjusted for age, sex, body mass index, ethnicity, hypertension, current smoking status, type 2 diabetes mellitus, HDL cholesterol, LDL cholesterol, triglycerides, apolipoprotein AI, and use of lipid medication. CHD indicates coronary heart disease; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; MI, myocardial infarction; and OR, odds ratio.