Table 4.
Associations of Prebeta‐1 HDL With CHD and MI Using the Combined Data From Cohorts 1 and 2
| ORs | CHD | MI | ||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| Total participants | ||||
| Absolute prebeta‐1 HDL tertile 1 | 1.00 (reference) | — | 1.00 (reference) | — |
| Tertile 3 | 2.37 (1.74–3.25) | <0.001 | 2.08 (1.42–3.04) | <0.001 |
| Total participants | ||||
| Percent prebeta‐1 HDL tertile 1 | 1.00 (reference) | — | 1.00 (reference) | — |
| Tertile 3 | 1.85 (1.33–2.58) | <0.001 | 1.69 (1.15–2.48) | 0.008 |
| Women | ||||
| Absolute prebeta‐1 HDL tertile 1 | 1.00 (reference) | — | 1.00 (reference) | — |
| Tertile 3 | 2.65 (1.80–3.88) | <0.001 | 2.50 (1.54–4.06) | <0.001 |
| Men | ||||
| Absolute prebeta‐1 HDL tertile 1 | 1.00 (reference) | — | 1.00 (reference) | — |
| Tertile 3 | 2.04 (1.19–3.51) | 0.010 | 1.96 (0.97–3.99) | 0.062 |
| Women | ||||
| Percent prebeta‐1 HDL tertile 1 | 1.00 (reference) | — | 1.00 (reference) | — |
| Tertile 3 | 2.00 (1.32–3.02) | 0.001 | 1.84 (1.15–2.96) | 0.011 |
| Men | ||||
| Percent prebeta‐1 HDL tertile 1 | 1.00 (reference) | — | 1.00 (reference) | — |
| Tertile 3 | 2.01 (1.14–3.54) | 0.016 | 1.90 (0.90–4.02) | 0.093 |
Data from both cohorts for those not taking lipid medication. Adjusted ORs and 95% CIs for tertiles of both percent prebeta‐1 HDL (percent of total plasma apolipoprotein AI) and absolute prebeta‐1 HDL for the 2 combined cohorts. For total participants: tertile 1, n=836; tertile 3, n=837. For women: tertile 1, n=474; tertile 3, n=474. For men: tertile 1, n=362; tertile 3, n=365. ORs were determined by logistic regression and adjusted for age, sex, body mass index, ethnicity, hypertension, current smoking status, type 2 diabetes mellitus, HDL cholesterol, LDL cholesterol, triglycerides, and apolipoprotein AI. CHD indicates coronary heart disease; HDL, high‐density lipoprotein; LDL, low‐density lipoprotein; MI, myocardial infarction; and OR, odds ratio.