Table 8.

Effect of Adding Prebeta‐1 HDL to Metabolic Syndrome‐Related Risk Factors on Risk‐Prediction Models

		AUC		NRI	IDI
		Change (95% CI)	P Value	Estimate (95% CI)	Estimate (95% CI)
Absolute	CHD	0.047 (0.021–0.073)	<0.001	0.341 (0.219–0.450)	0.019 (0.006–0.038)
Prebeta‐1 HDL	MI	0.052 (0.012–0.092)	0.011	0.402 (0.224–0.576)	0.012 (0.001–0.033)

Incremental change for 3 calibration statistics because of inclusion in risk models of top and bottom quintiles of absolute prebeta‐1 HDL compared to metabolic syndrome risk factors alone. The metabolic syndrome–related risk factors used in the models: low HDL <40 mg/dL for men and <50 mg/dL for women, high triglycerides defined as ≥150 mg/dL, obesity defined as a body mass index >30 kg/m², diabetes mellitus, hypertension. AUC in risk models that exclude prebeta‐1 HDL are 0.622 for CHD and 0.589 for MI. AUC indicates area under receiver operating characteristic curve; CHD, coronary heart disease; HDL, high‐density lipoprotein; IDI, integrated discrimination improvement index; MI, myocardial infarction; and NRI, net reclassification improvement index.