Table 3.
Within-group and between-group responses of the secondary outcome measures to the intervention from visit 1 to visit 2
| Outcome | Intervention | Control | ||
| n | Within-group difference | n | Within-group difference | |
| ∆ 6MWT (m) | 9 | 6 (−16, 45) | 8 | −17 (−74, 4) |
| ∆ SPPB | 9 | 0 (−1, 1) | 8 | 0 (0, 0) |
| ∆ Four-metre gait speed (m/s) | 9 | 0.03 (0.01, 0.06) | 8 | −0.04 (−0.09, 0.03) |
| ∆ QMVC (kg) | 9 | −0.1 (−1.9, 2.5) | 8 | −0.2 (−1.7, 2.0) |
| ∆ Rectus femoris cross-sectional area (mm2) | 9 | 18.0 (−32.6, 48.3) | 8 | 16.0 (−50.6, 33.0) |
| ∆ KBILD—psychological | 9 | 5.9 (−3.4, 12.8) | 9 | 0 (−7.2, 9.6) |
| ∆ KBILD—breathlessness and activities | 9 | 9.3 (−7.8, 13.8) | 9 | 0 (−8.4, 13.5) |
| ∆ KBILD—chest symptoms | 9 | 9.7 (−5.9, 16.7) | 9 | 9.7 (−5.9, 22.9) |
| ∆ KBILD—total score | 9 | 2.7 (−0.2, 7.4) | 9 | 0.1 (−2.2, 3.9) |
| ∆ LCADL—self-care | 9 | −1.0 (−2.0, 0.0) | 9 | 1.0 (−0.5, 1.5) |
| ∆ LCADL—domestic | 9 | 1.0 (−3.0, 4.5) | 9 | −1.0 (−3.0, −5.0) |
| ∆ LCADL—physical | 9 | 0.0 (−0.5, 0.5) | 9 | 0.0 (−1.0, 1.5) |
| ∆ LCADL—leisure | 9 | 0.0 (−1.0, 1.0) | 9 | 0.0 (−1.0, 1.5) |
| ∆ LCADL—total score | 9 | 0.0 (−5.0, 2.0) | 9 | 4.0 (−3.0, 10.0) |
| ∆ Daily step count | 5 | −270 (−504, 877) | 5 | −740 (−2026, −230) |
| ∆ Daily minutes spent in moderate-intensity PA | 5 | −3 (−20, 4) | 5 | −19 (−51, −5) |
| ∆ Daily minutes spent in light-intensity PA | 5 | 24 (5, 71) | 5 | −39 (−65, 15) |
| ∆ Daily minutes spent sedentary | 5 | −40 (−58, −21) | 5 | 54 (22, 86) |
Data reported as median (25th centile, 75th centile) difference.
KBILD domains and total score: range 0–100; higher scores indicate better health-related quality of life.
LCADL range: self-care: 0–20; domestic: 0–30; physical: 0–10; leisure: 0–15; total: 0–75; higher scores indicate greater impact on activities of daily living (ADL) performance.
KBILD, King’s Brief Interstitial Lung Disease questionnaire; LCADL, London Chest Activities of Daily Living questionnaire; 6MWT, 6 min walk test; PA, physical activity; QMVC, quadriceps maximum voluntary contraction; SPPB, Short Physical Performance Battery.