Table 3.
Ten-year change of outcome measures from eight participants in the prior VALIANT Study.
| Ten years ago mean (SD) | Current mean (SD) | Difference (95% CI)# | p-value | |
|---|---|---|---|---|
| MVICT (Kg) | 7.34 (6.28) | 5.67 (5.57) | −1.67 (−2.73, −0.62) | 0.0073 |
| SMA-FRS | 33.38 (3.25) | 28.75 (4.56) | −4.63 (−8.57, −0.68) | 0.0276 |
| 6MWT (meters) | 275.57 (157.11) | 195 (177.56) | −80.57 (−131.1, −30.07) | 0.0079 |
| FVC (liters) | 4.4 (0.94) | 3.88 (0.85) | −0.52 (−0.96, −0.09) | 0.0248 |
| CMAP amplitude (millivolts) | 7.9 (2.28) | 6.54 (3.19) | −1.36 (−2.86, 0.13) | 0.0679 |
#
Negative values indicate reduction in outcomes compared to measures obtained 10 years prior.