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. Author manuscript; available in PMC: 2021 Jun 3.
Published in final edited form as: FASEB J. 2020 Jan 9;34(2):3305–3317. doi: 10.1096/fj.201902915R

FIGURE 1.

FIGURE 1

N-WASP downregulation significantly decreased P aeruginosa induced permeability and VE-cadherin dissociation. A, RMVECs were challenged with P aeruginosa infection (MOI = 40), followed by ECIS measurement with or without N-WASP downregulation. B, Resistance value was measured up to 24h post P aeruginosa stimulation. Data are presented as the percentage of decreased resistance normalized to control (n = 7–8). C, Representative blot of co-immunoprecipitation assays showing increased association of N-WASP and VE-cadherin in response to P aeruginosa in RMVECs. D, Representative blot of co-immunoprecipitation assays showing the downregulation of N-WASP inhibited P aeruginosa induced dissociation of VE-cadherin and β-catenin in RMVECs. Data are presented as means ± SEM. *P < .01