Skip to main content
. Author manuscript; available in PMC: 2021 Jun 3.
Published in final edited form as: FASEB J. 2020 Jan 9;34(2):3305–3317. doi: 10.1096/fj.201902915R

FIGURE 6.

FIGURE 6

Conditional deletion of N-WASP protected against the development of pulmonary edema and improved survival in mice challenged with P aeruginosa. A, N-WASP floxed (N-WASPflox/flox) mice were instilled with adenoviral vector encoding Cre Recombinase (Ad-Cre) or adenoviral vector encoding control green fluorescent protein (Ad-GFP) (50 μL, 108 PFU), challenged with P aeruginosa (107 CFU), and followed by measurement of extravascular pulmonary edema (EVPE) 6 h post P aeruginosa challenge (n = 9–10 mice per group). The volume of EVPE in Ad-Cre instilled mice is significantly reduced when compared to mice instilled with control Ad-GFP in response to P aeruginosa challenge. B, Survival analysis showed improved survival in Ad-Cre instilled mice post P aeruginosa infection, when compared to the mortality in control Ad-GFP instilled mice (n = 18 mice per group). *P < .01