Fig 9. Experiment 4 edema at 72 h.

ICH significantly worsened NDS performance (A, p<0.0001 vs. baseline, Cohen’s d_z = 8.2 at 24 h, Cohen’s d = 45.2 at 72 h) and all forelimb placing at 24 h (B, p≤0.0125 vs. baseline, Cohen’s d_z = 3.5), for which the left forelimb deficits had resolved by 72 h (left and midline left, p≥0.107) but were still present in the right forelimb (right and midline right, p≤0.0415, Cohen’s d = 1.3). For forelimb placing, the dashed line at 0 denotes no impairment. No meaningful benefit of glibenclamide was found on either NDS (p≥0.2063), or forelimb placing of any paw (p≥0.4589). One rat had baseline data artificially set as 1 on the NDS and 9 for all forelimbs, and is indicated on all behaviour graphs by a star. Inclusion of this rat did not change our conclusions. ICH increased brain water content in both the ipsilateral striatum and cortex (C, p<0.0001), but was not affected by glibenclamide (p = 0.4096).