Table 2. Adverse events.
| Baseline | Chemo | Combo | Maintenance | ||||
|---|---|---|---|---|---|---|---|
| n = 21 | n = 21 | n = 13 | n = 12 | ||||
| Any Grade | Any Grade | Grade 3–4 | Any Grade | Grade 3–4 | Any Grade | Grade 3–4 | |
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | |
| Admission | 0 | 4 (19.0) | 4 (19.0) | 0 | 0 | 0 | 0 |
| Anorexia | 3 (14.2) | 5 (23.8) | 2 (9.5) | 1 (7.7) | 0 | 0 | 0 |
| Anxiety | 2 (9.5) | 2 (9.5) | 0 | 2 (15.4) | 0 | 1 (8.3) | 0 |
| Arthritis | 0 | 1 (4.8) | 0 | 0 | 0 | 2 (16.7) | 0 |
| Ascites | 5 (23.8) | 2 (9.5) | 1 (4.8) | 0 | 0 | 1 (8.3) | 0 |
| Aspiration | 0 | 1 (4.8) | 0 | 0 | 0 | 0 | 0 |
| Bloating | 4 (19.0) | 3 (14.2) | 0 | 0 | 0 | 4 (33.3) | 0 |
| Chills | 0 | 0 | 0 | 2 (15.4) | 0 | 0 | 0 |
| Confusion | 0 | 1 (4.8) | 0 | 0 | 0 | 0 | 0 |
| Constipation | 9 (42.9) | 9 (42.9) | 0 | 1 (7.7) | 0 | 1 (8.3) | 0 |
| Cough | 1 (4.8) | 2 (9.5) | 1 (4.8) | 0 | 0 | 1 (8.3) | 0 |
| Dehydration | 0 | 1 (4.8) | 1 (4.8) | 0 | 0 | 0 | 0 |
| Diarrhea | 2 (9.5) | 2 (9.5) | 0 | 2 (15.4) | 0 | 1 (8.3) | 0 |
| Dizziness | 1 (4.8) | 1 (4.8) | 0 | 0 | 0 | 0 | 0 |
| Dry eye | 0 | 0 | 0 | 0 | 0 | 1 (8.3) | 0 |
| Dyspepsia | 7 (33.3) | 3 (14.2) | 0 | 0 | 0 | 0 | 0 |
| Dysphagia | 0 | 0 | 0 | 0 | 0 | 1 (8.3) | 0 |
| Dyspnea | 2 (9.5) | 1 (4.8) | 0 | 2 (15.4) | 0 | 1 (8.3) | 0 |
| Ear tingling | 0 | 0 | 0 | 0 | 0 | 1 (8.3) | 0 |
| Edema | 0 | 2 (9.5) | 1 (4.8) | 2 (15.4) | 0 | 1 (8.3) | 0 |
| Fatigue | 6 (28.5) | 8 (38.1) | 3 (14.2) | 5 (38.5) | 0 | 4 (33.3) | 0 |
| Gastroparesis | 1 (4.8) | 0 | 0 | 0 | 0 | 0 | 0 |
| Headache | 1 (4.8) | 3 (14.2) | 0 | 3 (23.1) | 0 | 0 | 0 |
| Heart failure | 0 | 1 (4.8) | 1 (4.8) | 0 | 0 | 0 | 0 |
| Hematoma | 0 | 1 (4.8) | 1 (4.8) | 0 | 0 | 1 (8.3) | 0 |
| Hemolysis | 0 | 0 | 0 | 1 (7.7) | 1 (7.7) | 0 | 0 |
| Hip fracture | 0 | 0 | 0 | 0 | 0 | 1 (8.3) | 0 |
| Hypertension | 5 (23.8) | 2 (9.5) | 1 (4.8) | 3 (23.1) | 1 (7.7) | 1 (8.3) | 0 |
| Hypotension | 0 | 1 (4.8) | 0 | 0 | 0 | 0 | 0 |
| Ileal obstruction | 4 (19.0) | 2 (9.5) | 1 (4.8) | 0 | 0 | 0 | 0 |
| Insomnia | 4 (19.0) | 3 (14.2) | 1 (4.8) | 1 (7.7) | 0 | 0 | 0 |
| Malaise | 0 | 1 (4.8) | 0 | 0 | 0 | 0 | 0 |
| Memory impairment | 0 | 0 | 0 | 1 (7.7) | 0 | 0 | 0 |
| Mucositis | 1 (4.8) | 0 | 0 | 1 (7.7) | 0 | 0 | 0 |
| Nausea | 6 (28.5) | 13 (61.9) | 0 | 7 (53.8) | 0 | 1 (8.3) | 0 |
| Neuropathy | 4 (19.0) | 1 (4.8) | 0 | 0 | 0 | 2 (16.7) | 0 |
| Neutropenic fever | 0 | 1 (4.8) | 1 (4.8) | 0 | 0 | 0 | 0 |
| Pain | 8 (38.1) | 8 (38.1) | 2 (9.5) | 7 (53.8) | 0 | 6 (50.0) | 0 |
| Palpitations | 0 | 0 | 0 | 1 (7.7) | 0 | 0 | 0 |
| Pleural effusion | 0 | 1 (4.8) | 0 | 0 | 0 | 0 | 0 |
| Pulmonary hypertension | 0 | 1 (4.8) | 0 | 0 | 0 | 0 | 0 |
| Rash | 0 | 0 | 0 | 2 (15.4) | 0 | 1 (8.3) | 0 |
| Tachycardia | 0 | 1 (4.8) | 0 | 2 (15.4) | 0 | 2 (16.7) | 0 |
| Thyroid | 2 (9.5) | 3 (14.2) | 0 | 2 (15.4) | 0 | 3 (25.0) | 0 |
| Tinnitus | 0 | 1 (4.8) | 0 | 1 (7.7) | 0 | 0 | 0 |
| Upper respiratory | 0 | 1 (4.8) | 0 | 1 (7.7) | 0 | 0 | 0 |
| Urinary tract infection | 1 (4.8) | 0 | 0 | 1 (7.7) | 0 | 1 (8.3) | 0 |
| Vomiting | 3 (14.2) | 10 (47.6) | 2 (9.5) | 2 (15.4) | 0 | 0 | 0 |
| Weight loss | 1 (4.8) | 1 (4.8) | 0 | 0 | 0 | 0 | 0 |
| Weight gain | 0 | 2 (9.5) | 0 | 0 | 0 | 0 | 0 |