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. 2021 Mar 1;320(5):F761–F771. doi: 10.1152/ajprenal.00552.2020

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Published by the American Physiological Society

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Figure 2. — Proximal fluid reabsorption (J_prox) versus single-nephron glomerular filtration rate (SNGFR) before and during Na-glucose cotransporter (SGLT2) blockade (n = 135 tubular fluid collections). Data were combined from rats fed high-NaCl and low-NaCl diets. The exponential curve, J_prox = 5.08 + 0.00099 × SNGFR^2.36733 was a logistical fit to the raw data. The effect of SNGFR accounted for 75% of the total variance in J_prox. The effect of SGLT2 blockade accounted for 70% of the remaining variance in J_prox after controlling for SNGFR. The bar graph shows mean ± SE values for proximal reabsorption before and during SGLT2 blockade where J_prox′ is the value obtained for proximal reabsorption after adjusting for SNGFR.