Figure 4.

Effects of acute Na-glucose cotransporter (SGLT2) blockade on the glomerular filtration rate (GFR) and transcapillary pressure difference (ΔP) for individual animals where ΔP was measured directly in surface glomeruli. The values shown for ΔP were averaged from several glomeruli in that animal. A: ΔP before and during SGLT2 blockade shown separately for high-NaCl and low-NaCl diets. B: demonstration that GFR and ΔP were uncorrelated. Data for both diets were combined in this graph. C: corresponding changes in GFR and ΔP in response to SGLT2 blockade. SGLT2 blockade decreased both GFR and ΔP. However, greater decreases in ΔP were associated with lesser decreases in GFR (P = 0.04). This cannot be explained by isolated changes in preglomerular resistance (see discussion).