Figure 5.

Effects of acute Na-glucose cotransporter (SGLT2) blockade on glomerular filtration rate (GFR) and tubular stop-flow pressure (PSF) for individual animals. Values shown for PSF were averaged from several nephrons in that animal. A: PSF before and during SGLT2 blockade shown separately for high-NaCl and low-NaCl diets. B: demonstration that GFR and PSF were uncorrelated. Data for both diets were combined in this graph. C: corresponding changes in GFR and PSF in response to SGLT2 blockade. SGLT2 blockade reduced GFR but did not reduce PSF. The effects of acute SGLT2 blockade on GFR and PSF were uncorrelated. The PGC-lowering effect of SGLT2 inhibitor shown in Fig. 4 was not reflected in the PSF response. From the difference between ΔP and PSF responses, we infer that SGLT2 blockade reduces ΔP by eliciting a tubuloglomerular feedback response.