Table 2.
Serum electrolytes of wild-type, KLHL3R528H/R528H, KS-WNK1−/−, and double-mutant mice
| KLHL3+/+; KS-WNK1+/+ | KLHL3R528H/R528H; KS-WNK1+/+ | KLHL3+/+; KS-WNK1−/− | KLHL3R528H/R528H; KS-WNK1−/− | |
|---|---|---|---|---|
| Na+, mM | 151 ± 0.56 (n = 6) | 152 ± 0.56 (n = 6) | 150 ± 0.61 (n = 6) | 153 ± 0.58 (n = 6) |
| K+, mM | 4.5 ± 0.16 (n = 6) | 5.1 ± 0.10 (n = 6)* | 4.7 ± 0.12 (n = 6) | 5.0 ± 0.12 (n = 6)* |
| Cl−, mM | 118 ± 0.61 (n = 6) | 123 ± 0.22 (n = 6)* | 118 ± 0.53 (n = 6) | 122 ± 0.40 (n = 6)* |
| Ca2+, mM | 4.2 ± 0.3 (n = 6) | 4.5 ± 0.06 (n = 6) | 4.2 ± 0.12 (n = 6) | 4.3 ± 0.04 (n = 6) |
| pH | 7.3 ± 0.03 (n = 6) | 7.2 ± 0.01 (n = 6) | 7.3 ± 0.02 (n = 6) | 7.2 ± 0.01 (n = 6) |
| HCO3−, mM | 20 ± 0.76 (n = 6) | 14 ± 0.42 (n = 6)* | 17 ± 0.36 (n = 6) | 15 ± 0.52 (n = 6)* |
Data are means ± SE; n represents the number of mice included in the analyses. KLHL3, Kelch-like protein 3; WNK1, with no lysine kinase 1.
*P < 0.05 versus wild-type mice.