Skip to main content
. 2021 Apr 5;320(5):F883–F896. doi: 10.1152/ajprenal.00555.2020

Figure 4.

Figure 4.

High salt (HS) inhibits expression of Kir4.1, large-conductance K+ (BK) channels, and epithelial Na+ channels (ENaC). A, top: expression of Kir4.1, Kir5.1, and the BK channel α-subunit (BKα) in male wild-type [WT; floxed neural precursor cell expressed developmentally downregulated gene 4-like (Nedd4lfl/fl)] and kidney-specific neural precursor cell expressed developmentally downregulated protein 4-2 (Nedd4-2) knockout (Ks-Nedd4-2 KO) mice on normal salt (NS) or HS for 14 days. A, bottom: bar graph showing normalized band density of Kir4.1, Kir5.1, and BKα. B, top: expression of ENaCα, ENaCβ, and ENaCγ in male WT and Ks-Nedd4-2 KO mice on NS or HS for 14 days. B, bottom: bar graph showing normalized band density of ENaCα, ENaCβ, and ENaCγ. Significance was determined by two-way ANOVA.