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. 2021 Apr 5;320(5):F883–F896. doi: 10.1152/ajprenal.00555.2020

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Figure 7. — Deletion of neural precursor cell expressed developmentally downregulated protein 4-2 (Nedd4-2) abolishes the effect of dietary Na⁺ intake on NaCl cotransporter (NCC). A: Western blots showing the expression of phosphorylated (p)NCC and total (t)NCC in male floxed neural precursor cell expressed developmentally downregulated gene 4-like (Nedd4l^fl/fl) and kidney-specific Nedd4-2 knockout (Ks-Nedd4-2 KO) mice on normal salt (NS). B and C: immunoblot (IB) showing the expression of pNCC (at Thr⁵³) and tNCC in male Nedd4l^fl/fl and Ks-Nedd4-2 KO mice on different Na⁺ diets for 14 days, respectively. D: two bar graphs summarizing normalized band density of pNCC and tNCC in control and Ks-Nedd4-2 KO mice on low-salt (LS) and high-salt (HS) diets compared with NS. *Significance determined by one-way ANOVA.