Table 5.
Odds of death in 97 septic adults according to neutrophil expression of OLFM4 ≥ 37.6% compared with OLFM4 < 37.6% referent
| OR (95% CI) | P value | |
|---|---|---|
| Unadjusted | 5.80 (1.94–17.34) | 0.002 |
| Adjusted by age | 4.76 (1.55–14.60) | 0.006 |
| Adjusted by sex | 6.48 (2.08–20.17) | 0.004 |
| Adjusted by race | 7.47 (2.28–24.50) | 0.001 |
| Adjusted by closest WBC | 6.44 (2.08–19.93) | 0.001 |
| Adjusted by ANC | 6.20 (2.02–19.03) | 0.001 |
| Adjusted by band count | 6.91 (2.16–22.14) | 0.001 |
| Adjusted by active cancer | 4.96 (1.62–15.26) | 0.005 |
| Adjusted by SOFA score day 1 | 4.06 (1.22–13.53) | 0.02 |
| Adjusted by APACHE III | 4.06 (1.12–14.63) | 0.03 |
| Multivariate adjustment* | 4.82 (1.15–20.13) | 0.03 |
| Adjusted by shock in first 5 days | 4.83 (1.56–14.98) | 0.006 |
| Adjusted by need for mechanical ventilation first 5 days | 4.87 (1.58–14.98) | 0.006 |
*
Multivariate logistic regression of the association of OLFM4 ≥37.6% on mortality adjusted by age, sex, WBC, and APACHE III among 97 patients with sepsis. APACHE III ranges from 0 to 299, with higher scores indicating higher severity of illness. OLFM4, olfactomedin 4; OR, odds ratio; CI, confidence interval; WBC, white blood cell count; ANC, absolute neutrophil count; SOFA, sepsis-related organ failure assessment score; APACHE III, Acute Physiology and Chronic Health Evaluation severity of disease classification system.