From left to right, box pairs delineate the time intervals (TI) between symptom onset and arrival, symptom onset and CT, arrival (door) to CT, symptom onset to MR, arrival (door) to MR, and in between CT and MR. The left box of each pair denotes the patients included before November 1998 and the right box those from November 1998 to date. Each box shows the 25th to 75th percentile, whiskers show the 10th to 90th percentile, dots denote all observations above 90th and below 10th percentile. The horizontal line represents median values. P values (significance of difference between TIs before and after November 1) are given for each subset, and were calculated with the Mann-Whitney U-test