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Proposed algorithm for screening adults with hypertension for renin-independent aldosterone production, as adapted on the basis of new information in References 22** and 25, with permission. Those with a positive screen may be considered for early mineralocorticoid receptor antagonist (spironolactone or eplerenone) treatment. Those with an overtly positive screen should be referred to a specialist for a formal workup of primary aldosteronism. PRA, plasma renin activity.
