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Schematic representation of the 177Lu-labeled CNC NPs loaded with vemurafenib ([177Lu]Lu-CNC-V NPs). The green rod represents a cotton cellulose nanocrystal (CNC NP). The bifunctional radiometal chelator DOTA-NH2 is conjugated on the CNC surface via CDI-activated OH groups and further radiolabeled with 177Lu. Vemurafenib is entrapped on the surface of CNC by electrostatic interaction with the aid of poly-L-lysine as a capping agent.
