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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Nature. 2021 Jan 25;591(7849):293–299. doi: 10.1038/s41586-021-03237-4

Extended Data Figure 1. Furin cleavage site in SARS-CoV-2 spike.

Extended Data Figure 1.

A) Diagram of the coronavirus spike protein domains and cleavage sites. The sequences of the indicated group 2B coronaviruses were aligned according to the bounds of total spike, S1, N-terminal domain (NTD), Receptor binding domain (RBD), and C-terminal of S1 (CTS1) and S2. Sequence identities were extracted from the alignments, and a heatmap of sequence identity was constructed using EvolView (www.evolgenius.info/evolview) with SARS-CoV-2 WA1 as the reference sequence. B) Alignment of the furin cleavage site of SARS-CoV-2 and the corresponding amino acids identities found closely related group 2B CoVs. The PRRA insertion is unique to SARS-CoV-2 C) Representative plaque morphology of WT and ΔPRRA SARS-CoV-2.