Table 10.

Comparative pharmacokinetic parameters of different PV formulations and marketed cream (mean ± SD, n= 6).

PK parameters	Chitosan hydrogel loaded with PV powder (O2)	Chitosan hydrogel loaded with optimized PV-LO-SNEDDs (O3)	Marketed PV 1% cream
Cmax (ng/mL)	919 ± 112	2400 ± 290	1346 ± 205
Tmax (min)	60 ± 30	30 ± 15	60 ± 15
AUC 0–t (ng/mL h)	3011.1 ± 222.1	7413.2 ± 698.3	4134.2 ± 543.4
AUC0–inf (ng/mL h)	3922.1 ± 285.2	9564.5 ± 299.1	5611.2 ± 633.2
Kel (h−1)	0.655 ± 0.09	0.534 ± 0.05	0.605 ± 0.06