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. 2021 Jun 2;48(1):144. doi: 10.3892/ijmm.2021.4977

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Copyright: © Fang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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ATG16 expression is modulated by Beclin-1. ATG16 protein expression levels in the (A) renal cortex of IR model mice (n=6) and (B) H/R-exposed HK-2 cells (n=3) were detected by western blot. ^*P<0.05 vs. sham or control. (C) ATG16 protein expression was analyzed by western blot in HK-2 cells transfected with miR-30a-5p mimic, miR-30a-5p inhibitor, Beclin-1 siRNA, pcDNA3.1-Beclin-1 or a combination of the miR-30a-5p mimic with pcDNA3.1-Beclin-1 for 48 h, followed by exposure to H/R (n=3). ^*P<0.05 vs. H/R; ^#P<0.05 vs. H/R + mimic; ^&P<0.05 vs. H/R + inhibitor. ATG16, autophagy-related gene16; H/R, hypoxia/reoxygenation; miR, microRNA; siRNA, small interfering RNA.