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. 2021 May 26;48(1):138. doi: 10.3892/ijmm.2021.4971

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Copyright: © Ma et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Suppression of LBX2-AS1 inhibits proliferation and increases apoptosis of colorectal cancer cells. (A) LBX2-AS1 was silenced in HT29 and SW620 colorectal cancer cells following transfection with si-LBX2-AS1#1 or #2. (B) Cell Counting Kit-8 assay results showed that cell viability was inhibited in colorectal cancer cells transfected with si-LBX2-AS1. (C) The inhibitory effect of silencing LBX2-AS1 on colony formation was investigated in two colorectal cancer cells. (D) Flow cytometry assay results confirmed that the apoptosis of colorectal cancer cells was induced by si-LBX2-AS1. (E) Higher caspase-3 and caspase-9 expression levels were detected in colorectal cancer cells transfected with si-LBX2-AS1. ^**P<0.01 vs. si-NC. LBX2-AS1, LBX2 antisense RNA 1; si-, small interfering RNA; NC, negative control.