Table 3.
Sensitivity analysis for odds ratios of select neonatal outcomes by OSA status, stratified by gestational age <34 weeks, 34–36 weeks, 37–38 weeks, and ≥39 weeks, and controlling for newborns born to the same mother during the study period including twin/multiple gestations. (N = 1,190,758; that is the number of newborns with available gestational age data).
| Outcomes overall and stratified by gestational age | Crude OR or β (95% confidence interval) for OSA association with neonatal outcome | OR or β (95% CI), fully adjusteda for OSA association with neonatal outcome |
|---|---|---|
| Admitted to NICU | ||
| <34 weeks | 3.01 (1.59–5.70) | 2.51 (1.31–4.78) |
| 34–<37 weeks | 2.37 (1.87–3.01) | 1.85 (1.45–2.37) |
| 37–38 weeks | 2.92 (2.20–3.87) | 1.59 (1.18–2.16) |
| ≥39 weeks | 2.63 (1.94–3.57) | 1.75 (1.27–2.42) |
| Intubation at birth | ||
| <34 weeks | 1.10 (0.78–1.56) | 0.93 (0.65–1.34) |
| 34–<37 weeks | 1.89 (1.46–2.44) | 1.54 (1.18–2.00) |
| 37–38 weeks | 2.69 (1.81–3.99) | 1.46 (0.97–2.21) |
| ≥39 weeks | 2.58 (1.75–3.79) | 1.78 (1.20–2.64) |
| Total length of stay (days) | ||
| <34 weeks | 4.39 (−0.29 to 9.06) | 1.93 (−2.85 to 6.71) |
| 34–<37 weeks | 1.88 (0.97–2.80) | 1.14 (0.21–2.07) |
| 37–38 weeks | 1.29 (0.90–1.68) | 0.75 (0.36–1.14) |
| ≥39 weeks | 0.64 (0.46–0.83) | 0.35 (0.17–0.54) |
OSA: Obstructive sleep apnea. NICU: Neonatal intensive care unit.
Note: <34 weeks: 36,619 (3%).
34–36 weeks: 117,864 (10%).
37–38 weeks: 313,989: (26%).
≥39 weeks: 722,286: (61%).
a
Models adjusted for maternal obesity, race, age, multiple gestation, pre-pregnancy DM, gestational DM, pre-pregnancy HTN, gestational HTN, preeclampsia, tobacco use, alcohol use, and drug use.