Table 1. Baseline Characteristics by Quartiles of FGF23 in Community-Living Older Adults.
| Variable | Full cohort | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 |
|---|---|---|---|---|---|
| Range | <37 | 37–46 | 46.6 -- 60 | >60 | |
| N | 2763 | 688 | 695 | 691 | 689 |
| Age (years) | 75 (3) | 75 (3) | 75 (3) | 75 (3) | 75 (3) |
| Female | 1413 (55%) | 381 (55%) | 360 (52%) | 324 (47%) | 348 (51%) |
| Black | 1094 (40%) | 300 (44%) | 260 (37%) | 257 (37%) | 277 (40%) |
| Education | |||||
| < High School | 660 (24%) | 181 (26%) | 156 (23%) | 158 (23%) | 165 (24%) |
| Current Smoker | 266 (10%) | 83 (12%) | 62 (9%) | 60 (9%) | 61 (9%) |
| Body Mass Index (kg/m2) | 27.2 (4.8) | 26.7 (4.6) | 26.8 (4.7) | 27.4 (4.7) | 28.0 (5.1) |
| Diabetes | 1020 (37%) | 227 (33%) | 250 (36%) | 258 (37%) | 285 (41%) |
| Hypertension | 2130 (77%) | 495 (72%) | 511 (74%) | 547 (79%) | 577 (84%) |
| Systolic Blood Pressure (mmHg) | 134 (21) | 133 (20) | 133 (20) | 133 (21) | 135 (23) |
| Diastolic Blood Pressure (mmHg) | 70 (12) | 70 (12) | 70 (12) | 70 (12) | 70 (12) |
| HTN med use | 1582 (57%) | 330 (48%) | 363 (52%) | 411 (60%) | 478 (70%) |
| Total Cholesterol (mg/dL) | 206 (39) | 206 (38) | 208 (40) | 203 (38) | 205 (40) |
| Statin use | 440 (16%) | 96 (14%) | 87 (13%) | 131 (19%) | 126 (18%) |
| Prevalent CHD | 624 (23%) | 128 (19%) | 139 (20%) | 161 (23%) | 196 (28%) |
| Prevalent CHF | 111 (4%) | 14 (2%) | 18 (3%) | 20 (3%) | 59 (9%) |
| Prevalent stroke | 267 (10%) | 74 (11%) | 57 (8%) | 68 (10%) | 68 (10%) |
| Prevalent CVD | 778 (28%) | 175 (25%) | 174 (25%) | 193 (28%) | 236 (34%) |
| Serum albumin (g/dL) | 3.98 (0.31) | 3.99 (0.30) | 3.99 (0.31) | 3.97 (0.31) | 3.98 (0.33) |
| C-reactive protein (mg/L) | 2.9 [1.2, 6.5] | 2.9 [1.2, 6.1] | 2.7 [1.1, 6.1] | 2.7 [1.2, 6.1] | 3.5 [1.4, 8] |
| eGFR (ml/min/1.73m2) | 72 (18) | 77 (17) | 77 (17) | 72 (17) | 64 (20) |
| eGFR < 60 | 683 (25%) | 108 (16%) | 121 (17%) | 171 (25%) | 283 (41%) |
| Urine Albumin/Creatinine ratio (mg/g) | 7.6 [3.9, 19] | 7.2 [3.6, 15.8] | 7.0 [3.8, 16.3] | 7.3 [3.4, 17.5] | 6.6 [4.7, 31.3] |
| UACR ≥ 30 | 481 (18%) | 91 (13%) | 100 (15%) | 117 (17%) | 173 (26%) |
| Calcium (mg/dL) | 8.87 (0.43) | 8.80 (0.39) | 8.83 (0.41) | 8.89 (0.44) | 8.95 (0.47) |
| Phosphorus (mg/dL) | 3.55 (0.48) | 3.51 (0.44) | 3.52 (0.47) | 3.53 (0.48) | 3.65 (0.51) |
| Parathyroid hormone (pg/ml) | 34 [25, 45] | 32 [23, 42] | 31 [24, 41] | 34 [26, 45] | 38 [28, 56] |
Values are n, mean (SD), n (%), or median (interquartile range). CHF chronic heart failure, CVD cardiovascular disease, eGFR, estimated glomerular filtration rate; FGF23, Fibroblast growth factor 23; HDL, high density lipoprotein, LDL low density lipoprotein, UACR, urine albumin creatinine ratio.