Table 2. Associations of Intact FGF23 with Mortality and its Subtypes.
| All-cause Mortality | ||||
|---|---|---|---|---|
| Model 1 | Model 2 | |||
| Events/N | Incident Rate (%/year) | HR (95% CI) | HR (95% CI) | |
| FGF23 (per 2-fold higher) | 821/2763 | 4.1 | 1.45 (1.33, 1.58) | 1.24 (1.12, 1.37) |
| Cardiovascular Mortality | ||||
| Model 1 | Model 2 | |||
| Events/N | Incident Rate (%/year) | HR (95% CI) | HR (95% CI) | |
| FGF23 (per 2-fold higher) | 309/2763 | 1.5 | 1.56 (1.38, 1.76) | 1.31 (1.11, 1.54) |
| Cancer Mortality | ||||
| Model 1 | Model 2 | |||
| Events/N | Incident Rate (%/year) | HR (95% CI) | HR (95% CI) | |
| FGF23 (per 2-fold higher) | 245/2763 | 1.2 | 1.06 (0.87, 1.29) | 1.01 (0.83, 1.23) |
| Other Causes of Death | ||||
| Model 1 | Model 2 | |||
| Events/N | Incident Rate (%/year) | HR (95% CI) | HR (95% CI) | |
| FGF23 (per 2-fold higher) | 267/2763 | 1.3 | 1.61 (1.42, 1.84) | 1.33 (1.14, 1.56) |
| Sub-categories of “Other causes of Death” | ||||
| Pulmonary Related Deaths (includes COPD, Pneumonia and respiratory failure) | ||||
| Model 1 | Model 2 | |||
| Events/N | Incident Rate (%/year) | HR (95% CI) | HR (95% CI) | |
| FGF23 (per 2-fold higher) | 40/2763 | 0.15 | 1.38 (0.92, 2.07) | 1.40 (0.87, 2.27) |
| Dementia | ||||
| Model 1 | Model 2 | |||
| Events/N | Incident Rate (%/year) | HR (95% CI) | HR (95% CI) | |
| FGF23 (per 2-fold higher) | 56/2763 | 0.28 | 0.96 (0.62, 1.50) | 0.84 (0.56, 1.26) |
| GI bleed | ||||
| Model 1 | Model 2 | |||
| Events/N | Incident Rate (%/year) | HR (95% CI) | HR (95% CI) | |
| FGF23 (per 2-fold higher) | 8/2763 | 0.04 | 2.09 (1.38, 3.16) | 2.49 (0.86, 7.21) |
| Renal Failure | ||||
| Model 1 | Model 2 | |||
| Events/N | Incident Rate (%/year) | HR (95% CI) | HR (95% CI) | |
| FGF23 (per 2-fold higher) | 24/2763 | 0.12 | 2.48 (2.07, 2.96) | 1.25 (0.77, 2.03) |
| Sepsis | ||||
| Model 1 | Model 2 | |||
| Events/N | Incident Rate (%/year) | HR (95% CI) | HR (95% CI) | |
| FGF23(per 2-fold higher) | 15/2763 | 0.07 | 0.70 (0.34, 1.42) | 0.73 (0.31, 1.73) |
| Others | ||||
| Model 1 | Model 2 | |||
| Events/N | Incident Rate (%/year) | HR (95% CI) | HR (95% CI) | |
| FGF23(per 2-fold higher) | 124/2763 | 0.61 | 1.54 (1.26, 1.89) | 1.43 (1.12, 1.82) |
Model 1 = unadjusted analysis.
Model 2 = adjusted for M1 + diabetes, SBP, HTN meds, BMI, smoking, prevalent CVD, albumin, CRP, statin use, total cholesterol, calcium, phosphate, PTH, eGFR and UACR
BMI, Body mass index; CVD, cardiovascular disease; CRP, C-reactive protein; eGFR, estimated glomerular filtration rate; FGF23, Fibroblast growth factor 23; HTN, Hypertension; N, PTH, Parathyroid hormone, Number; UACR, urine albumin creatinine ratio.