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. 2021 Jun 4;40(12):2645–2649. doi: 10.1007/s10096-021-04284-5

Table 2.

Sensitivity of the nucleoprotein (NP), RBD-based, and NP/RBD-based IgG ELISAs at a specificity of 98.3%

Positive sera (%)
Time post infection No. of sera NP RBD NP/RBD
> 4 weeks 98

82.7

CI [73.74; 89.60]

92.9

CI [85.89; 97.11]

95.9

CI [89.85; 98.87]

4–10 weeks 48

95.8

CIa [85.70; 99.48]

97.9

CI [88.9; 99.95]

100.0

CI [92.60; 100.00]

6 months 50

70.0

CI [55.39; 82.14]

88.0

CI [75.69; 95.47]

92.0

CI [80.77; 97.78]

p-levelb 0.0008* 0.0585 0.0465*

aCI: 95% confidence interval

bComparison of the sensitivity 4–10 weeks versus 6 months post infection by the chi-squared test. Significant p-values are labeled with an asterisk