Table 1.
Haemodynamics, ventricular function and volumes and heart failure markers in pulmonary artery-banded (PAB) animals and controls
| Control (n = 6) | PAB (n = 5) | p | |
|---|---|---|---|
| Biometrics | |||
| Body weight (kg) | 37.7 (0.9) | 37.8 (4.5) | 1.0 |
| BSA (m2) | 0.8 (0.01) | 0.8 (0.06) | 1.0 |
| Haemodynamics | |||
| HR (min−1) | 81.8 (11.3) | 71.2 (7,9) | 0.1 |
| CI (L/min/m2) | 5.3 (1.1) | 4.1 (0.5) | 0.04 |
| SVi (ml/m2) | 64.6 (6.8) | 57.5 (2.2) | < 0.05 |
| SAP (mmHg) | 90.2 (1.7) | 78 (6) | 0.01 |
| DAP (mmHg) | 58 (9) | 52 (7) | 0.2 |
| MAP (mmHg) | 71.8 (9) | 63.8 (7.8) | 0.2 |
| SVRI (dyn·s/cm5/kg) | 1226 (355) | 1423 (97) | 0.2 |
| PVRI (dyn·s/cm5/kg) | 140 (81) | 358 (99) | 0.005 |
| RV Ea (mmHg/ml) | 0.58 (0.09) | 1.36 (0.4) | 0.001 |
| LV Ea (mmHg/ml) | 1.76 (0.28) | 2.09 (0.82) | 0.4 |
| Ventricle | |||
| RV Pmax (mmHg) | 27.4 (1.9) | 44.7 (9.7) | 0.02 |
| LV Pmax (mmHg) | 84 (5.6) | 68 (4.8) | < 0.05 |
| RV Pmean (mmHg) | 15.1 (1.0) | 23.2 (5.1) | 0.02 |
| LV Pmean (mmHg) | 39.9 (5.0) | 42.7 (5.3) | 0.4 |
| RV Pmin (mmHg) | 7.1 (1.1) | 6.6 (3.1) | 0.7 |
| LV Pmin (mmHg) | 7.6 (1.8) | 7.6 (1.4) | 1.0 |
| RV ESV (ml) | 36.6 (6.9) | 32.7 (18) | 0.7 |
| LV ESV (ml) | 40.2 (6.7) | 12.7 (8.1) | 0.03 |
| RV EDV (ml) | 65.3 (19.8) | 77.2 (10.1) | 0.2 |
| LV EDV (ml) | 82.3 (7.9) | 55 (4.9) | 0.02 |
| RV PRSW (mmHg·ml·ml−1) | 10 (3.5) | 15.2 (5.2) | 0.08 |
| LV PRSW (mmHg·ml·ml−1) | 44 (8.8) | 41.8 (17.9) | 0.8 |
| RV ESPVR (mmHg·ml−1) | 0.35 (0.12) | 1.07 (0.4) | 0.02 |
| LV ESPVR (mmHg·ml−1) | 0.9 (0.08) | 1.32 (0.5) | 0.5 |
| RV ESPVR V0 (ml) | − 31.8 (30.4) | 2.4 (11.7) | 0.04 |
| LV ESPVR V0 (ml) | − 38.3 (16.9) | − 42.6 (18.3) | 0.7 |
| RV dP/dtmax (mmHg/s) | 387.2 (93.6) | 542.8 (52.7) | 0.01 |
| LV dP/dtmax (mmHg/s) | 1081 (240) | 1385 (322) | 0.1 |
| RV Ea/ESPVR | 1.88 (0.8) | 1.34 (0.3) | 0.1 |
| LV Ea/ESPVR | 1.78 (0.43) | 1.8 (0.57) | 0.96 |
| RV EF (%) | 52.6 (6.6) | 52.8 (14) | 1.0 |
| LV EF (%) | 56 (5) | 71 (12) | 0.03 |
| RV dP/dtmin (mmHg/s) | − 378.5 (95) | − 677.5 (164.5) | 0.004 |
| LV dP/dtmin (mmHg/s) | − 1680 (121) | − 1395 (324) | 0.1 |
| RV tau (ms) | 75.4 (13.8) | 76.8 (17) | 0.9 |
| LV tau (ms) | 47 (5.3) | 62 (13.4) | 0.03 |
| RV EDPVR (mmHg/ml) | 0.16 (0.04) | 0.15 (0.05) | 0.7 |
| LV EDPVR (mmHg/ml) | 0.18 (0.06) | 0.23 (0.05) | 0.4 |
| Biochemistry | |||
| Lactate (mM) | 1.0 (0.3) | 1.7 (0.3) | 0.007 |
| NT-pro-BNP (pg/ml) | 6.3 (7.0) | 19.3 (8.9) | 0.02 |
Data are presented as means (SD)
BSA, body surface area. CI, cardiac index. DAP, diastolic artery pressure. dP/dtmax, maximum pressure development over time. dP/dtmin, minimum pressure development over time. Ea: arterial elastance. EDV, end-diastolic pressure. EDP, end-diastolic pressure. EDPVR, end-diastolic pressure–volume relationship. EF, ejection fraction. ESPVR, end-systolic pressure–volume relationship. ESPVR V0, end-systolic pressure–volume relationship x-axis intercept. ESP, end-systolic pressure. ESV: end-systolic pressure. HR, heart rate. LV, left ventricle. MAP, mean artery pressure. NT-proBNP: N-terminal pro-brain natriuretic peptide. Ped, minimum ventricular pressure. Pmean, mean ventricular pressure. Pmax, maximum ventricular pressure. PRSW, preload recruitable stroke work. Ped, minimum ventricular pressure. PRSW, preload recruitable stroke work. RV, right ventricle. PVRI, pulmonary vascular resistance index. SAP, systolic artery pressure. SVi: stroke volume index. SVRI, systemic vascular resistance index. tau, isovolumic relaxation constant