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. 2021 Apr 29;44(5):318–327. doi: 10.14348/molcells.2021.0057

Fig. 4. Protein arginine-modifications in CD4+ Th cells.

Fig. 4

Either TCR stimulation or cytokines may induce the expression and activity of protein arginine-modifying enzymes in CD4+ Th cells. PADs induce the conversion of Arg to citrulline of GATA-3 and RORγt and PRMTs integrate monomethyl and dimethyl group into Arg of GATA-3, RORγt, and FoxP3. In addition to the methylation and citrullination, GATA-3 is additionally acetylated by p300 HAT and subsequently promotes the Th2 cell development. Ac, acetylation; Cit, citrullination; G, glycosylation; Me, mono- & di-methylation.