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Regulation of the stability of HIF-1α by LSD1 in hypoxia. A Methylation of HIF-1α Lys32 or Lys391 residue by SET7/9 induces ubiquitination and degradation of HIF-1α. LSD1 removes the corresponding methyl groups and thereby stabilizes HIF-1α. B LSD1 prevents PHD2-induced hydroxylation and enhances K532 deacetylation of HIF-1α, thereby stabilizing HIF-1α. In addition, demethylation of RACK1 by LSD1 inhibits the interaction of RACK1 with HIF-1α, consequently stabilizing HIF-1α
