Fig. 3.

A) Discovery of an additional globular domain at the N-terminus of SAMD1 using GlobPlot [26]. Follow-up investigations of the N-terminal domain using structure prediction software, such as Phyre2 [27] and SWISS-MODEL [28], identifying this domain as a putative winged-helix domain. B) Discrepancy about the cellular localization of SAMD1 between UniProt [18], Protein Atlas [29], and the PSORT II prediction tool [30]. C) Own experiments strongly support a nuclear localization of SAMD1. See also Stielow et al.[1].