Table 5.
Linear mixed model regression parameters (standardized β) for the association of APOE-ε2 and APOE-ε4 genotypes with longitudinal rates of regional tau SUVR change over time. APOE-ε3ε3 participants were selected as the reference group for all comparisons. The model included age at baseline, sex, education, and diagnosis as covariates
APOE-ε2*time | APOE-ε4*time | |||
---|---|---|---|---|
β [95%CI] | p | β [95%CI] | p | |
ERC | − 0.10 [− 0.25, 0.07] | 0.396 | 0.08 [− 0.04, 0.15] | 0.200 |
ITC | − 0.07 [− 0.17, 0.07] | 0.505 | 0.08 [− 0.01, 0.15] | 0.147 |
Braak V/VI | − 0.01 [− 0.18, 0.18] | 0.629 | 0.10 [− 0.02 to 0.18] | 0.111 |
Aβ amyloid-β; ERC entorhinal cortex; ITC inferior temporal cortex; CI confidence intervals