Table 1.
Cohort characteristics
| [18F]Flortaucipir | [18F]RO948 | [18F]MK6240 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| CU | Non-AD | AD | CU | Non-AD | AD | CU | Non-AD | AD | |
| N, %F | 638 (57%) | 178 (45%) | 159 (60%) | 208 (56%) | 143 (41%) | 142 (54%) | 218 (66%) | 19 (59%) | 50 (56%) |
| Age, yr | 69.74 (9.03) | 68.16 (8.15) | 70.72 (10.38) | 75.29 (5.94) | 70.17 (9.15) | 74.14 (6.68) | 61.56 (19.78) | 62.52 (8.88) | 66.10 (10.01) |
| Education, yr | 14.70 (4.60) | 13.22 (5.71) | 11.87 (6.20) | 12.01 (3.72) | 12.54 (3.64) | 12.20 (4.40) | 15.72 (3.54) | 13.95 (4.20) | 14.00 (3.93) |
| MMSE | 28.96 (1.27) | 23.28 (6.21) | 20.40 (5.08) | 28.78 (1.23) | 25.27 (4.90) | 20.35 (4.12) | 29.22 (1.09) | 24.88 (7.06) | 18.49 (5.97) |
| APOE ε4 carrier, n (%)* | 107 (27%) | 32 (28%) | 76 (59%) | 82 (42%) | 53 (39%) | 102 (72%) | 58 (28%) | 2 (12%) | 24 (55%) |
| Aβ positive, n (%)** | 226 (35%) | 29 (19%) | 159 (100%) | 90 (43%) | 52 (34%) | 142 (100%) | 47 (22%) | 0 (0%) | 50 (100%) |
| SUVR, theory-driven (apriori) ROIs | |||||||||
| Entorhinal cortex | 1.14 (0.12) | 1.22 (0.21) | 1.74 (0.32) | 1.23 (0.22) | 1.22 (0.31) | 2.00 (0.40) | 0.93 (0.23) | 0.84 (0.21) | 2.42 (0.56) |
| Early tau | 1.19 (0.11) | 1.22 (0.19) | 1.88 (0.46) | 1.23 (0.18) | 1.22 (0.24) | 2.15 (0.66) | 0.87 (0.12) | 0.81 (0.09) | 2.80 (0.64) |
| Temporal meta-ROI | 1.18 (0.11) | 1.20 (0.16) | 1.88 (0.47) | 1.22 (0.18) | 1.22 (0.23) | 2.13 (0.66) | 0.86 (0.11) | 0.82 (0.09) | 2.84 (0.66) |
| Neocortical meta-ROI | 1.08 (0.08) | 1.13 (0.15) | 1.53 (0.38) | 1.23 (0.18) | 1.08 (0.16) | 1.51 (0.42) | 1.02 (0.10) | 0.98 (0.10) | 2.81 (0.97) |
*Missing APOE data: [18F]flortaucipir (237 CU, 64 non-AD, 32 AD); [18F]RO948 (3 non-AD); [18F]MK6240 (13 CU, 2 non-AD, 6 AD); **Aβ-status was missing in 31 non-AD subjects for [18F]flortaucipir