Table 2.
Summary of diagnostic performance and cut-offs for [18F]flortaucipir, [18F]RO948, and [18F]MK6240. AUC, area under the receiver operating curve value; 95% CI, 95% confidence interval
| AUC (95% CI) | Cut-point (95% CI) | Sensitivity (95% CI) | Specificity (95% CI) | |
|---|---|---|---|---|
| [18F]Flortaucipir | ||||
| AD vs CU | ||||
| Entorhinal cortex | 0.959 (0.941–0.977) | 1.30 (1.18, 1.35) | 92.30 (88.10–96.20) | 87.80 (85.10–90.30) |
| Early tau | 0.941 (0.917–0.965) | 1.35 (1.28, 1.42) | 86.20 (80.10–91.20) | 94.40 (92.30–95.90) |
| Temporal meta-ROI | 0.942 (0.917–0.965) | 1.36 (1.34, 1.40) | 86.20 (79.90–90.60) | 95.10 (93.40–96.70) |
| Neocortical meta-ROI | 0.901 (0.871–0.938) | 1.17 (1.13, 1.21) | 59.10 (50.90–66.70) | 99.20 (98.60–99.80) |
| Data-driven1 | 0.958 (0.942–0.983) | 1.33 (1.25, 1.41) | 89.30 (84.30–93.70) | 92.00 (89.90–94.10) |
| AD vs non-AD | ||||
| Entorhinal cortex | 0.919 (0.889–0.949) | 1.36 (1.29, 1.45) | 87.40 (82.40–92.30) | 85.40 (80.30–90.50) |
| Early tau | 0.925 (0.895–0.955) | 1.31 (1.21, 1.36) | 88.10 (83.00–92.50) | 89.90 (85.40–94.40) |
| Temporal meta-ROI | 0.926 (0.896–0.956) | 1.36 (1.31, 1.46) | 84.90 (79.30–90.60) | 93.30 (89.30–96.60) |
| Neocortical meta-ROI | 0.859 (0.816–0.901) | 1.19 (1.09, 1.23) | 78.70 (72.30–84.90) | 84.30 (78.90–89.30) |
| Data-driven2 | 0.925 (0.895–0.955) | 1.27 (1.20, 1.29) | 88.70 (83.70–93.10) | 89.30 (84.80–93.40) |
| [18F]RO948 | ||||
| AD vs CU | ||||
| Entorhinal cortex | 0.972 (0.956–0.987) | 1.44 (1.34, 1.52) | 94.40 (90.10–97.90) | 87.90 (83.70–92.30) |
| Early tau | 0.981 (0.969–0.994) | 1.38 (1.33, 1.43) | 90.10 (84.50–95.10) | 94.70 (91.40–97.60) |
| Temporal meta-ROI | 0.982 (0.969–0.994) | 1.34 (1.24, 1.39) | 92.30 (88.00–96.50) | 91.80 (87.90–95.20) |
| Neocortical meta-ROI | 0.942 (0.917–0.967) | 1.13 (1.08, 1.16) | 88.00 (82.40–92.90) | 76.00 (70.20–81.70) |
| Data-driven3 | 0.980 (0.967–0.993) | 1.39 (1.33, 1.48) | 89.40 (83.80–94.40) | 94.70 (91.40–97.60) |
| AD vs non-AD | ||||
| Entorhinal cortex | 0.954 (0.929–0.979) | 1.37 (1.18, 1.45) | 97.90 (95.10–100) | 83.90 (77.60–89.50) |
| Early tau | 0.955 (0.932–0.978) | 1.36 (1.29, 1.45) | 91.60 (86.60–95.80) | 88.10 (82.50–93.00) |
| Temporal meta-ROI | 0.955 (0.933–0.978) | 1.34 (1.27, 1.43) | 89.40 (84.50–94.40) | 88.80 (83.20–93.70) |
| Neocortical meta-ROI | 0.893 (0.855–0.931) | 1.13 (1.07, 1.18) | 85.20 (78.90–90.90) | 81.80 (77.50–87.40) |
| Data-driven4 | 0.956 (0.933–0.980) | 1.30 (1.18, 1.38) | 95.70 (92.30–98.90) | 86.70 (81.10–92.30) |
| [18F]MK6240 | ||||
| AD vs CU | ||||
| Entorhinal cortex | 0.969 (0.944–0.994) | 1.58 (1.14, 2.10) | 80.30 (73.20–86.60) | 93.70 (89.50–97.20) |
| Early tau | 0.985 (0.970–1) | 1.39 (1.29, 1.54) | 87.30 (81.70–92.90) | 90.90 (86.00–95.10) |
| Temporal meta-ROI | 0.989 (0.979–1) | 1.36 (1.16, 1.49) | 90.10 (84.50–94.40) | 88.80 (83.20–93.70) |
| Neocortical meta-ROI | 0.980 (0.957–1) | 1.25 (1.17, 1.30) | 68.30 (61.30–76.10) | 93.00 (88.80–96.50) |
| Data-driven5 | 0.986 (0.967–1) | 1.53 (1.46, 1.58) | 83.80 (77.50–89.40) | 90.20 (85.30–90.20) |
| AD vs non-AD | ||||
| Entorhinal cortex | 0.987 (0.969–1) | 1.61 (1.31, 2.29) | 80.30 (73.90–86.60) | 93.70 (89.50–97.20) |
| Early tau | 0.995 (0.988–1) | 1.31 (1.14, 1.37) | 93.70 (89.40–97.20) | 83.20 (76.90–88.80) |
| Temporal meta-ROI | 0.996 (0.987–1) | 1.34 (1.15, 1.42) | 92.90 (88.70–96.50) | 86.70 (81.10–92.30) |
| Neocortical meta-ROI | 0.992 (0.978–1) | 1.26 (1.16, 1.36) | 66.20 (58.50–73.90) | 93.00 (88.10–96.50) |
| Data-driven6 | 0.997 (0.991–1) | 1.23 (1.09, 1.32) | 97.90 (95.10–100) | 75.50 (68.50–82.30) |
1Inferior temporal cortex and parahippocampal gyrus; 2entorhinal cortex, amygdala, parahippocampus, and inferior temporal cortex; 3entorhinal cortex and amygdala; 4entorhinal cortex, parahippocampus, amygdala, fusiform gyrus, and inferior temporal cortex; 5inferior temporal cortex, fusiform gyrus, and middle temporal cortex; 6entorhinal cortex, amygdala, the inferior temporal cortex, the banks of the superior temporal sulcus, and the fusiform gyrus